On going research Projects
1. Electrospun fibers for interface tissue engineering Personnel involved: |
Electro spanning is a process by which fibers with sub-micron diameters can be obtained from an electrostatically driven jet of polymer solution. These fibers have a high surface area to volume ratio, which have numerous engineering applications. The objectives of this study are to evaluate electrospun fibers for interface tissue engineering . |
2. Implants for Inter-vertebral Disc (IVD) Polymer Personnel involved: |
The objectives of this project are to design and evaluate mechanical effectiveness of a polymer hydrogel with respect to a natural tissue, build an experimental setup to produce 6 degree of freedom spine motions (6DOF), develop and validate analytical and simulation models with the experimental model, and measure the mechanical responses from intact and implanted vertebral columns, and verify the measurements with finite element modeling under 6 DOF spine motions. |
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3. Improvement of cements for biomedical applications Personnel involved: |
A comparative study is required to evaluate the effect that different bioadditives and monomers have on the mechanical and biological performances on PMMA bone cement. The goal of this study is to determine the most suitable additives and alternative monomer for PMMA bone cement that can enhance the mechanical and biological performances of PMMA bone cement.
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4. Polyethylene glycol diacrylate (PEGDA) scaffold for tissue engineering applications Personnel involved: |
The goal of this research to design polyethylene glycol diacrylate (PEGDA) scaffold having internal architectures for nutrient distribution using UV-photopolymerization process for tissue engineering application. In particular we are assessing the photoinitiator and internal architectures effects on the stability and viscoelastic properties of PEGDA polymer. |
Current research grants:
1) UCO CURE-STEM award, FY 2008-present,"Interface tissue engineering research."
2) UCO oncampus Interdisciplinary grant, FY 2014-15, “Effect of plasma and peening treatments on the improvement of implant/biomaterial
interfaces."
3) INBRE undergraduate summer research program: Fatigue tests on titanium/PMMA interfaces."
Completed research grants:
1) "Development of a laboratory to enhance student learning using FEA and experimental technologies," FY 2008-09, UCO Innovative Technology for Transformative Learning Incentive Program.
2) "Measurement of Interfacial Strength of Engineered Tissue Constructs," Collaborator: B. Starley, Summer 2009, OK EPSCoR Research Opportunity Award.
3) UCO Start up grant, FY 2008-09, Sponsored by Office of Research & Grant.
4) NASA-EPSCoR travel grant, FY 2009-10.
5) UCO Interdisciplinary grant, FY 2009-10, The fracture toughness of bone-cement interface using digital image correlation: Experimental and numerical model, Collaborator: J. Juhao and G. Qian " Sponsored by Office of Research & Grant.
6) "Nanoscale fracture toughness measurement of bone and nanocomposite interfaces," Collaborator: C. Ownby, FY 2009-10, INBRE collaborative grant.
7) OKINBRE Release time grants," FY 2009-10.
8) INBRE undergraduate summer research program: The influence of orientation and particle size on the interface fracture of a bone-nanocomposite cement," Summer 2009.
9) N. Pradhan and M. Khandaker, FY 2009-10,RCSA grant: Determination of loading effect on bone-composite cement interface failure," Sponsored by Office of Research & Grant.
10) S. Sah and M. Khandaker, FY 2009-10,UCO RCSA grant: Numerical modeling of the cervical vertebra at Whiplash condition," Sponsored by Office of Research & Grant.
11) R. Fleenor and M. Khandaker, " FY 2009-10, UCO RCSA grant: Measurement of interfacial stress on a grafted bone-ligament interface," Sponsored by Office of Research & Grant.
12) M. Khandaker and S. Madihally, " pH-dependent swelling of composite hydrogels for the assessment of cell-dependent mechanical integration of engineered tissue constructs," Summer 2010, OK EPSCoR Research Opportunity Award.
13) M. Khandaker, "2010 INBRE undergraduate summer research program," Summer 2010.
14) M. Khandaker (PI), FY 2010-11, UCO regular grant: Measurement of Extrinsic Toughness of a Nanocomposite Bone Cement Using Digital Image Correlation Techniques," Sponsored by Office of Research & Grant.
15) M. Khandaker (PI), FY 2010-11, INBRE small equipment grants," Sponsored by OKINBRE.
16) N. Pradhan and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Effect of the Hydroxypatite and Chitosan Nanoparticales on the Fractural Strength of Polymethymethacrylate (PMMA) Bone Cement," Sponsored by Office of Research & Grant.
17) S. Sah and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Experimental Study of the Cervical Vertebra in a Static Whiplash Condition," Sponsored by Office of Research & Grant.
18) R. Fleenor and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Recreation of Bone-Cartilage Interfacial Strength," Sponsored by Office of Research & Grant.
19) S. Tarantini and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Numerical modeling of the cervical vertebra at Whiplash condition," Sponsored by Office of Research & Grant.
20) K. Duggan and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Measurement of Interfacial Strength of Engineered Tissue Constructs," Sponsored by Office of Research & Grant.
21) OKINBRE Release time grants," FY 2011-12.
22) S. Tarantini and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: “Evaluation of Nanocomposite Bone Cement Cytotoxicity Level," Sponsored by Office of Research & Grant.
23) M. Khandaker (PI), FY 2011-12, UCO regular grant: Evaluation of Composite Cement Mantles Fatigue Failure of Steel-composite Cement Joints: an experimental hip simulator and a finite element analysis model," Sponsored by Office of Research & Grant.
24) UCO Information technology funding, , FY 2012-13"Acquisition of ANSYS."
25) UCO regular grant, , FY 2012-13 “Improvement of prosthesis/cement interface by modified PMMA cement for orthopedic applications."
26) OKINBRE large equipment grants. , “Acquistion of rheometer for biomedical applications.”
27) UCO RCSA grant. , FY 2012-13 Faculty mentor. Zhaotong Meng research, "Exothermic Temperature Measurements of Novel PMMA Bone Cements."
28) UCO RCSA grant. FY 2012-13, Faculty mentor. Zheila Azartash-Namin research, "Physical Properties of Electroactive Composite Using Silicone Elastomer."
29) OKINBRE Mini Grant. (PI), , FY 2013-14,“The impact of nanofibers on the failure functions of Titanium/cement interface.”
30) UCO regular grant, FY 2013-14, “Augmentation of implant/cement interfaces by nanofibers and nanoparticles."
31) UCO Information technology funding , FY 2013-14, "Renewal of ANSYS academic research."
32) UCO RCSA grant, FY 2013-14, Faculty mentor. Zhaotong Meng research, "Exothermic Temperature Measurements of Novel PMMA Bone Cements."
33) INBRE undergraduate summer research program: The effect of nanoparticle type and concentration on the curing properties of PMMA bone cement ," Summer 2013.