RESEARCH AND GRANTS


Left to right: Zheila, Kooroush,Aston, Aayush, me, Utsaha, Khiet, Zhaotang

Completed projects funded by research grants:

1) UCO CURE-STEM award, FY 2008-13,"Interface tissue engineering research," Funded in the amount of $7,500 per academic year.

2) OKINBRE Mini Grant. (PI), FY 2013-14,“The impact of nanofibers on the failure functions of Titanium/cement interface.” Funded in the amount of $34,158.

3) UCO regular grant, FY 2013-14, “Augmentation of implant/cement interfaces by nanofibers and nanoparticles," Funded in the amount of $7,475.00.

4) UCO Information technology funding , FY 2013-14, "Renewal of ANSYS academic research," Funded in the amount of $4,999.99.

5) UCO RCSA grant, FY 2013-14, Faculty mentor. Zhaotong Meng research, "Exothermic Temperature Measurements of Novel PMMA Bone Cements." Funded in the amount of $500.

6) "Development of a laboratory to enhance student learning using FEA and experimental technologies," FY 2008-09, UCO Innovative Technology for Transformative Learning Incentive Program, Fund amount $7,000.

7) "Measurement of Interfacial Strength of Engineered Tissue Constructs," Collaborator: B. Starley, Summer 2009, OK EPSCoR Research Opportunity Award, Fund amount $10,000.

8) UCO Start up grant, FY 2008-09, Sponsored by Office of Research & Grant, Fund amount $500.

9) NASA-EPSCoR travel grant, FY 2009-10, fund amount $1,500.

10) UCO Interdisciplinary grant, FY 2009-10, The fracture toughness of bone-cement interface using digital image correlation: Experimental and numerical model, Collaborator: J. Juhao and G. Qian " Sponsored by Office of Research & Grant, Fund amount $8,000.

11) "Nanoscale fracture toughness measurement of bone and nanocomposite interfaces," Collaborator: C. Ownby, FY 2009-10, INBRE collaborative grant, Fund amount $50,050.

12) OKINBRE Release time grants," FY 2009-10, Fund amount $18,976.

13) INBRE undergraduate summer research program: The influence of orientation and particle size on the interface fracture of a bone-nanocomposite cement," Summer 2009, Fund amount $2,200.

14) N. Pradhan and M. Khandaker, FY 2009-10,RCSA grant: Determination of loading effect on bone-composite cement interface failure," Sponsored by Office of Research & Grant, Fund amount $500.

15) S. Sah and M. Khandaker, FY 2009-10,UCO RCSA grant: Numerical modeling of the cervical vertebra at Whiplash condition," Sponsored by Office of Research & Grant, Fund amount $500.

16) R. Fleenor and M. Khandaker, " FY 2009-10, UCO RCSA grant: Measurement of interfacial stress on a grafted bone-ligament interface," Sponsored by Office of Research & Grant, Fund amount $500.

17) M. Khandaker and S. Madihally, " pH-dependent swelling of composite hydrogels for the assessment of cell-dependent mechanical integration of engineered tissue constructs," Summer 2010, OK EPSCoR Research Opportunity Award, Fund amount $10,000.

18) M. Khandaker, "2010 INBRE undergraduate summer research program," Summer 2010, Fund amount $4,400.

19) M. Khandaker (PI), FY 2010-11, UCO regular grant: Measurement of Extrinsic Toughness of a Nanocomposite Bone Cement Using Digital Image Correlation Techniques," Sponsored by Office of Research & Grant, Fund amount $3,444.

20) M. Khandaker (PI), FY 2010-11, INBRE small equipment grants," Sponsored by OKINBRE, Fund amount $15,000.

21) N. Pradhan and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Effect of the Hydroxypatite and Chitosan Nanoparticales on the Fractural Strength of Polymethymethacrylate (PMMA) Bone Cement," Sponsored by Office of Research & Grant, Fund amount $500.

22) S. Sah and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Experimental Study of the Cervical Vertebra in a Static Whiplash Condition," Sponsored by Office of Research & Grant, Fund amount $500.

23) R. Fleenor and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Recreation of Bone-Cartilage Interfacial Strength," Sponsored by Office of Research & Grant, Fund amount $500.

24) S. Tarantini and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Numerical modeling of the cervical vertebra at Whiplash condition," Sponsored by Office of Research & Grant, Fund amount $500.

25) K. Duggan and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: Measurement of Interfacial Strength of Engineered Tissue Constructs," Sponsored by Office of Research & Grant, Fund amount $500.

26) OKINBRE Release time grants," FY 2011-12, Fund amount $6,868.

27) S. Tarantini and M. Khandaker (Faculty mentor), FY 2010-11, UCO RCSA grant: “Evaluation of Nanocomposite Bone Cement Cytotoxicity Level," Sponsored by Office of Research & Grant, Fund amount $500.

28) M. Khandaker (PI), FY 2011-12, UCO regular grant: Evaluation of Composite Cement Mantles Fatigue Failure of Steel-composite Cement Joints: an experimental hip simulator and a finite element analysis model," Sponsored by Office of Research & Grant, Fund amount $4,550.

29) UCO Information technology funding, , FY 2012-13"Acquisition of ANSYS," Funded in the amount of $4,988.59.

30) UCO regular grant, , FY 2012-13 “Improvement of prosthesis/cement interface by modified PMMA cement for orthopedic applications," Funded in the amount of $7,500.00.

31) OKINBRE large equipment grants. , “Acquistion of rheometer for biomedical applications,” FY 2012-13Funded in the amount of $35,000.

32) UCO RCSA grant. , FY 2012-13 Faculty mentor. Zhaotong Meng research, "Exothermic Temperature Measurements of Novel PMMA Bone Cements." Funded in the amount of $500.

33) UCO RCSA grant. FY 2012-13, Faculty mentor. Zheila Azartash-Namin research, "Physical Properties of Electroactive Composite Using Silicone Elastomer." Funded in the amount of $500.

On going research Projects

1. Electrospun fibers for interface tissue engineering

Personnel involved:
Aayush Khadka
Utsaha KC

Electro spanning is a process by which fibers with sub-micron diameters can be obtained from an electrostatically driven jet of polymer solution. These fibers have a high surface area to volume ratio, which have numerous engineering applications. The objectives of this study are to evaluate electrospun fibers for interface tissue engineering .

2. Implants for Inter-vertebral Disc (IVD) Polymer

Personnel involved:
Kooroush Azartash
Zheila Azartash
Ashton Williams

The objectives of this project are to design and evaluate mechanical effectiveness of a polymer hydrogel with respect to a natural tissue, build an experimental setup to produce 6 degree of freedom spine motions (6DOF), develop and validate analytical and simulation models with the experimental model, and measure the mechanical responses from intact and implanted vertebral columns, and verify the measurements with finite element modeling under 6 DOF spine motions.

3. Improvement of cements for biomedical applications

Personnel involved:
Melville Vaughan
Zhaotang Meng

A comparative study is required to evaluate the effect that different bioadditives and monomers have on the mechanical and biological performances on PMMA bone cement. The goal of this study is to determine the most suitable additives and alternative monomer for PMMA bone cement that can enhance the mechanical and biological performances of PMMA bone cement.

2. Polyethylene glycol diacrylate (PEGDA) scaffold for tissue engineering applications

Personnel involved:
Andrew Armstrong
Zhaotang Meng

The goal of this research to design polyethylene glycol diacrylate (PEGDA) scaffold having internal architectures for nutrient distribution using UV-photopolymerization process for tissue engineering application. In particular we are assessing the photoinitiator and internal architectures effects on the stability and viscoelastic properties of PEGDA polymer.


Research Facilities:

1. Evex Micro Tensile Tester for Scanning electron microscope

2. BUEHLER®. IsoMet® Low Speed Saw. PRECISION SECTIONING SAW

3. Nikon SMZ 1000 steromicroscope

4. Sonic Vibra-cell ultrasonic liquid processor VCX 130

5. Nikon TS100F Inverted Microscope with Fluorescence

6. MICROSENSE NON CONTACT MEASUREMENT SYSTEM

7. Qualitest mechanical tester

8. Newport high precision actuators and controllers (model # LTA-HL, LTA-HS)

9. NUAIRE Class II, Type A2 Biological Safety Cabinet

10. Micro Strain micro-miniature DVRT displacement sensor

11. NUAIRE NU-4750 US AUTOFLOW WATER-JACKETED CO2 INCUBATOR

12. Futek 250 gram, 1 lb, 10lb, and 50 lb load cell sensor and display system

13. Tuttnauer Autoclaves and sterilizers model 2340

14. Flexiforce pressure sensor and data acquistion system

15. Kenmore Refrigerator (2-10 deg) and freezer (-20 deg)

16. Epsilon Lateral extensometer and clip on gage for COD

17. Gamma high power voltage source


18. Malvern CVO rheometer